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Usually, polymer vesicles are prepared by self-assembly of amphiphilic block copolymers by the solvent switch method or the organic-solvent free method. Polymer vesicles prepared by self-association of block copolymers, which are of great interest because of their potential application in fields such as materials science and biochemistry. Thus, the size of the PICsomes can be controlled by selecting an appropriate preparation method. The hydrodynamic size of the PICsomes increased with concentration of the diblock copolymer solutions before mixing. A spherical hollow vesicle structure was observed in TEM images.
The R h value and aggregation number ( N agg) of PICsomes in 0.1 M NaCl was 78.0 nm and 7770, respectively. Maximum hydrodynamic radius ( R h) for the PICsome was observed at a neutral charge balance of the cationic and anionic diblock copolymers. The PICsomes were characterized using 1H NMR, static abd dynamic light scattering, transmittance electron microscopy (TEM), and atomic force microscopy.
Combining two solutions of oppositely charged diblock copolymers, PMPC- b-PMAPTAC and PMPC- b-PAMPS, led to the spontaneous formation of polyion complex vesicles (PICsomes). The degree of polymerization for PMPC, cationic PMAPTAC, and anionic PAMPS blocks was 20, 190, and 196, respectively. Polymers were synthesized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization using a PMPC macro-chain transfer agent. Diblock copolymers consisting of a hydrophilic poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) block and either a cationic or anionic block were prepared from (3-(methacrylamido)propyl)trimethylammonium chloride (MAPTAC) or sodium 2-(acrylamido)-2-methylpropanesulfonate (AMPS).
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